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Moreover, I-124 labeled cancer cell membrane-mimicking nanovesicles 124I-P/C@CMLvs loaded with multi-flavonoid VI (PPVI) and CDDP, among them the loaded PPVI promotes p53 deubiquitination and stimulates ROS production thereby triggering ferroptosis amplification mediated by GPX4 signaling and pyroptosis mediated by the NLRP3/GSDMD/Caspase-1 axis, which significantly enhances the infiltration of immune cells in tumor tissues, including DCs, CD8 + T cells and CD4 + T cells, and further promotes tumor regression when combined with anti-PD-L1 therapy (228)

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