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doi:10.1056/NEJMoa2301972 PubMed: This landmark study demonstrated 24.2% mean weight loss at 48 weeks with the 12mg dose in 338 adults with obesity, establishing retatrutide as the most effective obesity medication tested to date

"Accordingly, this product is an unapproved new drug." Three of the companies, Prime Sciences, Lovega, and Gram Peptides, were also cited for marketing bacteriostatic water used to dilute the medication

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Butt AM, Jones HC, Abbott NJ

For compounds that give negative results, the completion of either option of the standard test battery, performed and evaluated in accordance with current recommendations, will usually provide sufficient assurance of the absence of genotoxic activity and no additional tests are warranted

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