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A third suggests cycling 5 days on, 2 days off, while a fourth insists on daily administration without breaks

The homogenate was centrifuged at 10.000 rpm for 20 min to remove cell debris, nuclei, erythrocytes, and mitochondria 40

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Therefore, abnormally high expression of associated membrane proteins which mediate drug efflux is one of the causes leading to chemotherapy resistance ( Figure 1 )