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Researchers are actively trying to find useful biomarkers that can predict patient response to methotrexate

When to seek medical advice: Severe pain, swelling, or signs of infection at injection sites Allergic symptoms (rash, difficulty breathing, facial swelling) Unexplained fatigue, jaundice, or dark urine Any concerning symptoms following injection Patients should always disclose use of lipotropic injections to their GP, as this information may be relevant for diagnosis and management of other conditions

However, the recommended dosage for treating deficiency may vary depending on the severity of the deficiency and your overall health

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This isnt perfect, but its better than using shorter-acting opioids (as discussed in the subsection below)

Accessed 6/29/2017