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Treatment will be deemed to have failed in these patients, and they will be further studied and treated outside the trial according to normal clinical practice

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Excessive intracellular iron, as a powerful oxidant, can deteriorate DNA, RNA, proteins, and lipids, leading to oxidative damage [60, 61]

One of the most notable characteristics of thiols is their strong and often pungent odor, which results from sulfurs larger atomic radius and lower electronegativity compared to oxygen

The phase 3 SUMMIT study in people with HFpEF and obesity [54] and the phase 2 SYNERGY-NASH study [55] are ongoing