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& Wu, H.-Q

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contaminant phages were titrated on E

Damage-associated molecular patterns, such as high mobility group box 1 (HMGB1), initiate this phenotypic shift by engaging signaling pathways like toll-like receptor 4 (TLR4) and the receptor for advanced glycation end products (RAGE), which in turn activate downstream effectors, including nuclear factor kappa-B (NF-B) and the NOD-like receptor thermal protein domain associated protein 3 (NLRP3) inflammasome (Tastan and Heneka, 2024

However, in cultures of the SEV group, the reduction of CCL3 by B12 did not reach statistical significance and intracellular IL-1B levels were very low, close to the detection limit of the technique, suggesting that, in severe COVID-19, leukocytes are more prone to promptly export IL-1B