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Since pediatric population encompasses a wide age group, drug therapy in children should be evidence-based

Additionally, hormonal changes associated with menopause and menstruation may influence vitamin B12 absorption and metabolism, potentially contributing to vitamin B12 deficiency

[,] To avoid renal damage caused by hemoglobin sedimentation, intravenous fluids may be administered with or without bicarbonate, and in certain situations, a blood transfusion may be required

This protective response might be an attempt to reduce the levels of oxidative stress but alternatively might accelerate ferroptosis in case of excessive HMOX-1 activation [30]

There are conflicting data on the effects of kavapyrones on CNS levels of dopamine and serotonin (14)

Houstis, N., Rosen, E