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Am J Physiol 252 ( Regulatory Interactive Comp Physiol 21): R693R698

doi: 10.1007/s11064-021-03335-9 9

In addition, ROS can activate the expression of the nuclear transcription factorkappa, which upregulates the expression of many genes involved in MS, such as tumor necrosis factor and nitric oxide synthase, among others, leading to mitochondrial dysfunction and energy deficits that result in mitochondrial and cellular calcium overload

Ethosomes are vesicular carriers constructed out of high concentrations of ethanol and phospholipids, designed specifically to improve drug delivery through the skin