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The elevated MMP-13 and ADAMTS-5, coupled with reduced TIMP-3, result in poor tissue remodeling, hampering re-epithelialization and angiogenesis 91,92

BSO reduces GSH pools to below 1% in many cell types 25,26 and is generally well tolerated, including in studies on other intracellular bacteria where it was used at millimolar concentrations 15,17

This is largely regulated by the vagus nerve, the key highway of the gut-brain axis

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For patients with a diagnosed deficiency, B12 injections may be given daily or weekly during the initial correction phase, then monthly for maintenance

Side effects from asthma treatments, particularly prolonged usage of steroids, might include immune system suppression, weight gain, and elevated blood pressure