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doi: 10.3748/wjg.v20.i10.2492 201 LiuWJiangHLiuXHuSLiHFengYet al

Limonin attenuated calcium influx, preventing oxidative damage and loss of viability

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These scientists concluded as follows: Although there are many opinions about the risks or benefits of antioxidant supplementation, the only supportable conclusions based on the present research are that there is no evidence of antioxidant supplementation causing harm alongside cancer therapy, except for smokers undergoing radiotherapy. The caveat for smokers is based on a trial in head and neck cancer patients in which supplementing with alpha-tocopherol and beta-carotene during radiotherapy had a negative impact on rates of cancer recurrence and death in participants who smoked during the trial (Meyer 2008)

As a ferroptosis resistance factor, FSP1 compensates for GPX4 deletion by mediating the reduction of oxidized coenzyme Q to ubiquinol, a lipophilic antioxidant, thereby preventing the propagation of lipid peroxidation [76, 77]