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Additional metabolites identified in the 0-24-h urine after oral administration of [2,3- 14 C]acrolein to rats (2.5 mg/kg) include 3-hydroxpropionic acid (6-30% relative abundance), malonic acid (trace), and N -acetyl- S -(2-carboxy-2-hydroxyethyl)-cysteine (8-18%), an end-product metabolite of GSH addition to glycidaldehyde [62] (Fig

In fungal infection models, upon macrophage uptake of Mucor circinelloides, ATF1 and ATF2 are activated to regulate a series of gene networks, including Chi1 and Aqp1, thus enhancing fungal survival within the phagosome

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A multi-center randomized controlled trial in China revealed that lactulose suppresses the growth of ammonia-producing bacteria such as Streptococcus salivarius , reduces ammonia production and absorption, and concurrently stimulates the proliferation of beneficial sugar-fermenting bacteria like Bifidobacterium and Lactobacillus (81, 91)

DOI: 10.1016/j.fertnstert.2019.11.008