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As an example of such a multipronged approach, the Neotone formulation simultaneously targeting melanocytes, fibroblasts, and endothelial cells with the combination of five actives (niacinamide, licorice extract, diacetylboldine, a DKK1 agonist, and an inhibitor of EDN-1 synthesis) was found to be as effective as hydroquinone 4% cream in the management of facial melasma, while inducing fewer side effects [214]

Regulation of Nrf2 signaling

Different populations of human locus ceruleus neurons contain heavy metals or hyperphosphorylated tau: implications for amyloid- and tau pathology in Alzheimers disease

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While the NQA assessment team stuck to the visit plan, they dipped into other areas when justified or if relevant questions arose

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