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Upon receipt, it is recommended to store the lyophilized powder at -20C for long-term stability

This is known as a synergistic effect

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Receptor Downregulation Findings and Study Design Implications A well-documented finding in the research literature is that continuous IGF-1 receptor activation leads to receptor downregulation after approximately four to six weeks, reducing cellular responsiveness to further stimulation

Oral bioavailability of NAD+ and its precursors is poor, which is why supplements at the wellness shop are mostly a waste of money