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As mentioned above, MIEAP expression is defective not only in oncocytic thyroid tumors but also in conventional thyroid cancers in which BRAF V600E is the main driver mutation, and our results indicate that mitophagy is critical for suppressing carcinogenesis in thyroid cancers in general

Cell 159 , 789799 (2014)

5i, j), thus blocking access of other substrates to its catalytic pocket