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This is achieved through downregulation of -catenin transcription factor-7-like-2 (TCF7L2) mRNA and suppression of downstream Wnt/-catenin signaling target genes, including Cyclin D1, c-Myc, Snail, Vimentin, matrix metalloproteinase 2 (MMP2), and MMP9, in human CRC cells (Pooja et al., 2014)

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Building upon the understanding of quercetins physicochemical properties, pharmacokinetics, bioavailability toxicological studies and safety, it is crucial to explore its potential therapeutic applications

doi: 10.1016/j.beem.2010.08.006 20 KaravolosS