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In addition, overexpression of the 51 dimer activates CAFs, promoting tumor fibrosis, which acts as a protective barrier against treatment penetration (Wheelock et al., 2008)

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Erythropoiesis is initiated in hypoxic states when the HIF triggers the expression of the EPO gene

Shangguan, D

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For peptides not yet formally included in a pharmacopeia, these references are less directly applicable, but they indicate the laboratory is working from validated, recognized methods rather than unspecified in-house procedures