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BMC Plant Biol 16:87112

Within the cell, glutamine is deamidated to glutamate by glutaminase (GLS)

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The major translational challenges include achieving sufficient tumor-specific accumulation over healthy tissues (especially for intravenous delivery), overcoming the heterogeneity and adaptability of the TME that may diminish catalytic efficacy, and addressing potential long-term toxicity of Pt accumulation