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doi: 10.1189/jlb.3MR0316-106R [DOI] [PMC free article] [PubMed] [Google Scholar] 205

doi: 10.1016/j.phrs.2014.08.002 104 MitchellLATingleAJMacWilliamLHomeCKeownPGaurLKet al

NAD(P)H oxidase associated superoxide production in human placenta from normotensive and pre-eclamptic women

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In the cells, the interaction of excess superoxides with excess nitric oxide results in the generation of peroxynitrite which specify the chronic disease conditions of stroke, myocardial infarction, chronic heart failure, diabetes, circulatory shock, chronic inflammatory diseases, cancer, and neurodegenerative disorders [12]

The underlying pharmacology is well described in peer-reviewed literature, though clinical effect sizes vary by indication, dosing, individual factors, and adherence