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However, these peptides behave very differently due to structural modifications that affect their half-life, receptor sensitivity, and tissue selectivity

Regardless of the cause, knee pain often worsens over time and can become so debilitating that walking or standing becomes painful

Phys Med Biol 47(17):3225-49, 2002

To make matters worse, for alcoholics suffering from depression, it also leads to poor response to antidepressant medication

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