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315 Mutations in mitophagy-related genes, including PRKN , PINK1 , PDX1 , and CLEC16A , have been shown to contribute to the development of T2DM in both humans and mice

This occurs when EGL-9 adds a hydroxyl group onto a proline residue in HIF-1

doi: 10.1126/scitranslmed.aay1809 254 ZhaoN.LiuC.-C.vanA.MartensY

J.WieshammerG.ZhangG.McGrathS

Zileuton, a LOX inhibitor, protects neurocytes from glutamate-induced oxidative damage by inhibiting ferroptosis (Liu et al., 2015)