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Acknowledgements The authors would like to thank Debbie Day (Axis, a division of Spirit Medical Communications Group Ltd.) for medical writing and editorial assistance

GLP-1 RAs not only ameliorate insulin resistance and microvascular injury [84], which are significant determinants of depression in T2DM, but also enhance dopamine metabolism and stimulate growth factor signaling pathways, suggesting potential neuroprotective functions [85,86]

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