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The heavy subunit catalyzes formation of -glutamylcysteine, whereas the light subunit increases affinity for glutamate and decreases the inhibition by glutathione (Seelig et al., 1984

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J Steroid Biochem Mol Biol 117:5666 Cavalieri EL, Devanesan P, Bosland MC, Badawi AF, Rogan EG (2002) Catechol estrogen metabolites and conjugates in different regions of the prostate of noble rats treated with 4-hydroxyestradiol: implications for estrogen-induced initiation of prostate cancer