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Finally, a four-year, multicenter, clinical trial in 421 diabetic patients with distal symmetric sensorimotor polyneuropathy found no difference between oral administration of 600 mg/day of lipoic and placebo on the primary endpoint, a composite score that assessed neuropathic impairment of the lower limbs and nerve conduction (78)

LCMS/MS and pathway analysis LCMS/MS samples were prepared according to a Filter-aided Sample Preparation (FASP) method 69

Some patients are accompanied by cutaneous symptoms such as urticaria, angioedema, flushing or gastrointestinal symptoms (Trinh et al., 2018)

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