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These materials may contribute to neurodegeneration through mechanisms involving the induction of mitochondrial dysfunction, redox imbalance, apoptosis, autophagy, impaired lysosomal activity, cytoskeletal damage, vesicle trafficking perturbations, neuroinflammation and microglial activation

In some regions, the use of glutathione for skin whitening purposes may not be regulated or approved by health authorities, raising questions about its safety and legality

By protecting neurons from mast-cell-induced toxicity, these peptides may help to preserve gut motility and vagal tone, reduce neuroinflammation and abdominal pain, improve digestion and absorption through ENS integrity, and stabilise mood and cognitive function via gutbrain communication

Sci Rep 7:9393 Acknowledgments We thank Jing Zhao for giving some helps in performing the experiments and thank the AJE company for providing the language editing help

NHS was added at 1:1 dilution as a negative control

However, when precipitated from supersaturated solution, niclosamide equilibrated to much lower final supernatant concentrations, reflective of more stable polymorphs at each pH that were also apparent for niclosamide from other suppliers and cosolvates