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Its precise origin and specificities (peripheral, central, objective or perceived) remain debated

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INFLAMMATION : Excessive alcohol consumption has also been shown to encourage the release of cytokines, the immune system's signaling molecules

In post-acute viral syndromes, a loss of integrity of the gut mucosal barrier follows the virus-induced local inflammation (228231)

Interoceptive signals may reach the brain in many ways

Beyond its role in neurotransmitter release, S has also been implicated in modulating neuronal excitability and firing or signaling patterns (Janezic et al., 2013