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Substrate is shown in yellow, GS in green and residues C/S13, V12 and the backbone of A11 in magenta

Arch Biochem Biophys 463:211217

pluvialis is often realized by a two-stage cultivation method, where cell growth and astaxanthin induction are separated into two steps [18, 41, 73]

However, concomitant anti-inflammatory treatment is indicated during this procedure, as delayed tear drainage leads to the persistence of toxic and inflammatory factors on the ocular surface [20]

Tirzepatide, branded as Zepbound, is FDA-approved and achieves around 20.9% weight loss in trials

Titration of S-verapamil (Sigma-Aldrich) and ligand 4e (synthesized as previously reported 62 ) was carried out by 2 l additions of ligands solubilized in 50% DMSO