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5-Amino-1MQ doesn't act on appetite, it works by inhibiting NNMT, which shifts cell metabolism toward fat oxidation and muscle preservation

McReynolds MR, et al

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To determine the effect of NNMT inhibitor on NNMT activity in the pre-adipocytes and differentiated adipocytes (810 4 cells/well seeded prior to beginning differentiation), cells were treated with 30 M inhibitor for 24 h

NNMT inhibitors show promise in suppressing obesity and increasing metabolic health