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For example, Au@DTDTPA(Gd) NPs combined with X-ray radiotherapy significantly inhibit the invasive capacity of escape cells from GBM spheroids, and attenuate their invasiveness and stem cell-like characteristics (such as SOX2 downregulation) by reducing MMP-2 secretion and activity and inducing mitotic catastrophe (150)

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In contrast, methylation patterns and functions in invertebrates (and especially marine invertebrates) are more variable and less well characterized [5, 72]