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The SOD absence accompanied with the swells of mitochondrial structure and mitochondrial cristae changes, further decreased ATP production and elevated level of oxidative DNA damage can be observed which eventually impact the RPE function

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doi: 10.1038/s42255-024-01137-1 138 LamKCArayaREHuangAChenQDi ModicaMRodriguesRRet al

Gene-environment interactions in Parkinson's disease: specific evidence in humans and mammalian models

Rathi et al

Increased levels of ROS and lipid peroxidation products and/or decreased levels of antioxidant enzymes, such as superoxide dismutase (SOD) and catalase, and antioxidant compounds, such as glutathione, have been reported in both NAFLD/NASH patients as well as a variety of animal models of NAFLD 9,10,11,12,13,14