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It tends to be most prominent during perimenopause and usually resolves after menopause, and it is not normally a sign of permanent decline

Chan School of Public Health, (5)University of California, San Francisco, (6)Boehringer Ingelheim Pharmaceuticals, (7)Iccb-Longwood Screening Facility, Harvard Medical School, (8)Broad Institute Background: Chronic liver injury leads to hepatic stellate cell (HSC) activation and transdifferentiation into HSC myofibroblasts, which produce the extracellular matrix (ECM) responsible for fibrosis