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Conditions for which this effect has been demonstrated are: glutaric aciduria II, methyl malonic aciduria, propionic acidemia, and medium chain fatty acylCoA dehydrogenase deficiency.7,8 Autointoxication occurs in these patients due to the accumulation of acylCoA compounds that disrupt intermediary metabolism

Glutathione, the key ingredient, is believed to work by inhibiting melanin synthesis, the process responsible for skin pigmentation

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however, these trials excluded participants with significant cardiovascular disease

Understanding the holobiont: how microbial metabolites affect human health and shape the immune system