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Therefore, understanding the underlying mechanisms of tamoxifen resistance in breast cancer is critical to reducing the prevalence of treatment resistance in breast cancer and associated mortality

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The ORR was higher than that observed in a separate cohort of 58 patients with dMMR/MSI-H mCRC with disease progression on or following fluoropyrimidine-, oxaliplatin-, and irinotecan-based chemotherapy who received nivolumab alone, with an ORR of 28% with 67% having response durations of 6 months