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This increases actual concentration slightly a 53mg vial reconstituted with 2mL yields 26.5mg/mL instead of 25mg/mL

Insulin normally suppresses gluconeogenesis while promoting lipogenesis, however, under insulin resistant states such as T2D, hepatic lipogenesis remains insulin sensitive and suppression of gluconeogenesis is insulin resistant, leading to a metabolic state called selective hepatic insulin resistance (199)

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They're newer to the scene, which means less historical data but early reviews are promising