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It was discovered that UPS controls the function of RTECs via the transcription factors sterol regulatory element-binding protein 1 (SreBP-1), GATA4/GSA1 route, STAT1/TGF-1 pathway, and PINK1/Parkin pathway

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It is important to note, however, that other in vitro and in vivo investigations suggest high glucose levels can directly impact BBB integrity through reduced TJ proteins

Vieira, M

Stojsavljevi A, Rovanin B, Krsti et al (2020) Risk assessment of toxic and essential trace metals on the thyroid health at the tissue level: the significance of lead and selenium for colloid goiter disease

Specifically, it was seen that inflammatory infiltrates were greatly reduced in the livers of the MODA-treated mice