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On the other hand, ROS will be generated to attack the skeleton protein, which will lead to the morphological changes of endothelial cells and cracks in the cell layer (He S

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Future studies should prioritize defining the precise abundance threshold of Akkermansia muciniphila that balances its beneficial and deleterious effects on the intestinal barrier, investigating the molecular mediators (e.g., specific metabolites or surface proteins) that underpin its dual regulatory role, and developing targeted interventions (e.g., precision probiotics or microbiota modulators) to sustain its homeostatic levelswith the goal of ultimately mitigating OA progression via the gut-joint axis

doi: 10.1002/1878-0261.12975 68 Martin-GallausiauxCSalesseLGarcia-WeberDMarinelliLBeguet-CrespelFBrochardVet al

It enhances the immune system by protecting cells from oxidative damage