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Another study replicated the results when researchers evaluated the IGF-1 effects on muscle damage in mice

One important caveat: IGF-1 LR3 retains its ability to bind the insulin receptor (IR), forming hybrid IGF1R/IR complexes

T.LauritzenH

Elevated intracellular cAMP levels activate protein kinase A (PKA), which phosphorylates multiple downstream targets including transcription factors like CREB (cAMP response element-binding protein)