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For quantification of [ 15 N 13 ]-CNCbl, the influence of trace CNCbl originating from the endogenous cobalamins in the soybean flour was negligible due to addition of high amounts of exogenous CNCbl as internal standard

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It should be noted that these studies measured total Cbl levels, but as previously mentioned, the biologically available form of Cbl, TCN2-Cbl, comprises only approximately 2030% of the total Cbl level, which may lead to a significant number of false negatives for clb deficiency

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and related to local anesthetics (allergic reactions