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Summary and Conclusion Melanin hyperpigmented disorders affect a large population in the world and lead to negative impacts on quality of life

D.KhorasanizadehS

doi:10.1016/s0300-483x(00)00210-9 Cao AH, Wang J, Gao HQ, Zhang P, Qiu J

The cumulative impact of impaired HPA regulation combined with compromised glucocorticoid and insulin receptor activity, aggravated by inflammatory cytokines, might explain the high rate of metabolic syndrome, diabetes, dyslipidemia, and osteoporosis in the bipolar population (88, 204)

S1C, clusters 1, 3, and 19 represent TECs and enriched pathways of Metabolism pathways, Glyoxylate and dicarboxylate metabolism, PPAR signaling, and other pathways during the injury, which provided us with hints for subsequent studies