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In such cases, proportionately more B12 is bound to holoTC leading to elevated serum holoTC levels

For those with severe deficiencies or chronic conditions, more frequent injections may be necessary

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Injection Techniques : Safe and effective intramuscular injection methods for each vitamin

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Those with a longer duration of NSAID treatment, who are concomitantly using oral corticosteroids, aspirin, anticoagulants, selective serotonin reuptake inhibitors (SSRIs), or serotonin and norepinephrine reuptake inhibitors (SNRIs), and who have a history of liver disease, peptic ulcers, GI bleeding, or bleeding disorders are at an increased risk