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doi: 10.3389/fphys.2022.954948 Received 27 May 2022 Accepted 28 July 2022 Published 25 August 2022 Volume 13 - 2022 Edited by Robert Roghair, The University of Iowa, United States Reviewed by Jeffrey Segar, Medical College of Wisconsin, United States Michael Satterfield, Texas A&M University, United States Updates Copyright 2022 Stremming, White, Donthi, Batt, Hetrick, Chang, Wesolowski, Seefeldt, McCurdy, Rozance and Brown

The question of sermorelins impact on estrogen usually comes up because some of the benefits of sermorelin, like improved muscle tone, skin thickness, and fat metabolism, overlap with those of hormone replacement therapy (HRT)

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(Beans, fruits, and vegetables do not seem to increase risk, even if they are high in purines

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These deficiencies are not just coincidental but can exacerbate molecular dysregulation such as impaired insulin signaling, altered steroidogenesis and redox imbalance (1820)