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A 2019 study published in Obesity the journal of The Obesity Society analyzed nearly 14,000 adults (84% female) and found that patients who used phentermine for longer than 12 months lost significantly more weight at 6 months, one year, and two years compared to those who stopped at three months

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In a 16-week study of nightly GHRH-(1-29) dosing in older adults, nocturnal growth-hormone output stayed elevated across the full treatment period and IGF-1 rose and remained above baseline, with no sign of the pituitary becoming desensitized to nightly stimulation over those 16 weeks (Khorram et al., 1997)