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When substances are administered intravenously, they bypass the digestive system and are immediately available for use by the body

K.WiltbankM

Accili D, Drago J, Lee EJ, Johnson MD, Cool MH, Salvatore P, et al

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Small-molecule drugs and nearly all biologicsincluding peptides, proteins, antibodies, and nucleic acidsfail to cross the BBB at therapeutically relevant levels