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R 3a and R 3b are independently selected from H, Ci

Fluorine, a highly electronegative atom, is important in medicinal chemistry, where a single fluorine incorporation in small molecules can increase pharmacokinetic and physicochemical properties, improve metabolic stability and enhance membrane permeation 41

It is not surprising that some patients feel depressed considering the amalgam of other psychological and physical symptoms that may assail them

As IRIS-KS is the result of responses by a recovered immune system to KS-causing pathogen, i.e., KSHV, treatment of KSHV-seropositive, HIV-positive patients with a combination of antiretroviral (HAART) and anti-KSHV chemotherapeutics is expected to yield positive results

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Xia et al., 2018)