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Ultimately, the convergence of tumor-intrinsic and microenvironmental interventions, including strategies aimed at remodeling or reprogramming myeloid-driven suppressive niches, offers an opportunity to collapse evolutionary escape routes rather than simply delay them

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This design aims to reduce immunogenicity, extend systemic circulation, and maintain enzymatic activity

Embryos were collected after 30 min and placed in E3 medium (60 mmolL NaCl, 0.67 mmolL KCl, 0.3 mmolL NaHCO, 0.9 mmolL CaCl, pH 7.2) containing methylene blue