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It is important to acknowledge that the relationships we found between AC levels, MDD diagnosis, depression severity and depression profiles may be explained to some extent by shared distal environmental and lifestyle factors (e.g., comorbid somatic diseases, sedentary behavior, smoking, high-fat diet, alcohol consumption [61,62,63,64] that could act as confounder or mediators of the association

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featureCounts: an efficient general purpose program for assigning sequence reads to genomic features

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MMA needs to be diagnosed by laboratory methods, and relatively high concentrations of methylmalonic acid and methyl citrate in patient urine, as determined by GC/MS, can lead to a definitive diagnosis of the disorder