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Moreover IL-12 amplifies both growth rates and cytotoxic activities among NK cells alongside CD4+ and CD8+ T lymphocytes, resulting in increased production of perforin and granzyme B, which are key molecules essential for CTLs capacity to eradicate tumor cells (74, 75)

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P62-Keap1-Nrf2-ARE Nuclear factor erythroid 2-related factor 2 (Nrf2), is a key transcription factor in the antioxidant response