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Inhibitors of GLS, GDH, GCPII, GTK, or other key enzymes could be used in combination with standard chemotherapy treatments to increase their overall effectiveness (Fig

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We discuss the cellular and molecular mechanisms of agingand how specific behaviors, such as fasting, regular exercise and NAD-boosting compounds like NMN, can activate the body's natural longevity pathways

Others, such as corynoxine, target upstream phosphatases such as protein phosphatase 2A to dually inhibit AKT signaling (98), whereas Gboxin and its analog Y9 trigger lysosomal dysfunction and autophagic impairment (99)