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Normal metabolic processes and environmental factors such as toxins, radiation, and inflammation generate them

Interestingly, it was found that the active Rac1, Cdc42, and RhoA not only affected the morphological plasticity of activated spines, but also could diffuse to nearby spines and lower the threshold of sLTP induction in these spines, a phenomenon typically referred to as heterosynaptic plasticity or synaptic crosstalk