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In vivo transcriptome changes of human white blood cells in response to vitamin D

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Known diabetic cataract models include the in vivo streptozotocin diabetes model 7 , galactose diet-loaded model 8 , and Nile grass rats 9

Instead, oxidative stress appears to be the underlying mechanism of glutamate-induced beta-cell death

We also studied the consequences of PA treatment on the expression of other well-known ferroptosis-related genes and found that PA induced a decreased expression of two key anti-ferroptotic genes: the gluthatione peroxidase 4 (GPX4) and the ferroptosis suppressor protein 1 (FSP1) and an enhanced expression of two key pro-ferroptotic genes: the arachidonate 15-lipoxygenase (ALOX15) and the acyl-CoA synthetase long chain family member 4 (ACSL4)