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REST directly bound to the promoter region of GCLM (152 to 132, GCCGCAGGCCAAGGGCCAGTC) to repress its transcription, while knockdown of REST increased GCLM transcription and enhanced GCL enzymatic activity, leading to upregulation of GSH and GPX4 to reduce lipid peroxidation and ferroptosis in AKI

185,186 Furthermore, regular physical activity improves overall health and quality of life and reduces the risk of related conditions, such as diabetes, obesity, and hypertension, that are associated with more rapid progression of CKD

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